{"product_id":"type-1-diabetes-advances-in-understanding-and-treatment-100-years-after-the-discovery-of-insulin-second-edition","title":"Type 1 Diabetes: Advances in Understanding and Treatment 100 Years After the Discovery of Insulin, Second Edition","description":"\u003cp\u003eType 1 diabetes, \u003cbr\u003esometimes called juvenile-onset or insulin-dependent diabetes, is an \u003cbr\u003eautoimmune condition in which the β cells in the pancreas that produce \u003cbr\u003einsulin are destroyed by the body's immune system. The disease affects \u003cbr\u003emillions of individuals, but for more than 100 years, diet and insulin \u003cbr\u003einjections were the only effective treatment. Recent discoveries, \u003cbr\u003ehowever, have led to new therapies and finally the promise of a cure.\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e \u003cp\u003eWritten and edited by experts in the field, this new collection from \u003cem\u003eCold Spring Harbor Perspectives in Medicine\u003c\/em\u003e\u003cbr\u003e discusses exciting research that has increased our understanding of the\u003cbr\u003e mechanisms underlying development of type 1 diabetes. The contributors \u003cbr\u003ediscuss immunological, genetic and environmental contributions to \u003cbr\u003edisease susceptibility, the part β cells play, and how interactions with\u003cbr\u003e the immune system drive pathogenesis. They examine the failure of \u003cbr\u003eimmune tolerance, the role of T cells, specific features of \u003cbr\u003eautoimmunity, and the importance of neoantigens in the disease, as well \u003cbr\u003eas the important question of whether it is β cells or the immune system \u003cbr\u003ethat becomes dysfunctional first.\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e \u003cp\u003eIn addition, the volume \u003cbr\u003ereviews the incredible progress in development of treatments for type 1 \u003cbr\u003ediabetes, including novel therapies that rebalance the immune system and\u003cbr\u003e pancreatic islet-cell transplantation. The long journey to approval of \u003cbr\u003eteplizumab to treat individuals at high risk is also covered. The new \u003cbr\u003ebook will therefore be of interest to all endocrinologists and \u003cbr\u003eimmunologists seeking to learn more about this disease but also those \u003cbr\u003eworking in drug development.\u003c\/p\u003e\u003cbr\u003e","brand":"Cold Spring Harbor Laboratory Press","offers":[{"title":"Default Title","offer_id":51974568935655,"sku":"9781621825074","price":79.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0449\/4075\/5096\/files\/imageloader_c5ced325-e493-4f54-b585-6c7c5180fdb3.jpg?v=1776047247","url":"https:\/\/arvidabookco.com\/products\/type-1-diabetes-advances-in-understanding-and-treatment-100-years-after-the-discovery-of-insulin-second-edition","provider":"Arvida Book Co.","version":"1.0","type":"link"}